xylocaine pdf

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Pharmacokinetics of xylocaine
After receiving xylocaine in the middle xylocaine is well absorbed is absorbed from the gastrointestinal tract (average 85%). Cmax achieved through 5 h Reception immediately before dinner low fat does not affect the pharmacokinetic parameters xylocaine.
The "first pass " through the byproduct xylocaine biotransformed to form active beta - metabolites. Plasma protein binding is 95%.
Concentration active xylocaine metabolite in human systemic circulation is less than 5 %.
Excreted unchanged image and group metabolites , mainly in the bile - 60-85 %, 10-15% - in the form of inert metabolites disappears kidneys.


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